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单碱基编辑技术（Base editor）是基于CRISPR系统的新型靶基因定点修饰技术，它不需要产生DNA双链断裂（DSB）及DNA模板就可以对基因组特定碱基进行高效的替换。单碱基编辑技术可以应用于通过精确改变单个碱基实现关键氨基酸的改变，可以通过引入终止密码子实现基因的功能缺失突变，还可以对一些启动子区的调控位点进行...
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